Fractures: Pioglitazone has been associated with an increased incidence of bone fracture for female patients. You and your doctor should consider the risk of fractures. Talk to your doctor if you have any concerns. Heart failure: Pioglitazone can cause fluid buildup in the body, which may lead to congestive heart failure.
This medication should not be used by anyone who has any degree of heart failure, or anyone who is at risk of heart failure including people with swelling due to fluid buildup. If you develop fluid buildup or swelling, shortness of breath, fatigue, or excessive weight gain while taking this medication, you should consult your doctor immediately.
Liver: Although liver problems have not been observed with pioglitazone, another similar medication has caused liver problems in a small number of people. You should report any signs of liver problems abdominal or stomach pain, dark urine, loss of appetite, nausea or vomiting, unusual tiredness or weakness, or yellow eyes or skin to your doctor at once. Use with other diabetes medications: Pioglitazone should not be used with insulin. It should not be used in combination i.
Vision: Pioglitazone may cause fluid to build up in the eye macular edema causing vision changes. If you experience any change to your vision, contact your doctor.
Pregnancy: Pioglitazone has not been studied for use by pregnant women. This medication should not be used during pregnancy. In general, blood sugar should be controlled during pregnancy by using insulin injections. If you become pregnant while taking this medication, contact your doctor immediately. Breast-feeding: It is not known if pioglitazone passes into breast milk. If you are a breast-feeding mother and are taking this medication, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.
Children: The safety and effectiveness of using this medication have not been established for children. If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:. How well did Actoplus Met work for you? Did you experience many side effects while taking this drug?
How likely would you be to recommend Actoplus Met to a friend? Back Submit. Uses of Actoplus Met Back to Top. Manufacturer Back to Top. Takeda Pharmaceuticals America, Inc. Generic Back to Top.
Metformin And Pioglitazone For more information on this medication choose from the list of selections below. Actoplus Met is part of the drug class: Combinations of oral blood glucose lowering drugs. Tell your doctor if you have any side effect that bothers you or that does not go away. Actoplus Met Interactions Back to Top. Actoplus Met Precautions Back to Top. Serious side effects have been reported with Actoplus Met including the following: Congestive heart failure.
Tell your healthcare provider right away if you have some or all of the following symptoms of congestive heart failure. Extreme tiredness Weakness or discomfort Unusual or unexpected stomach pain Decreased appetite Deep and rapid breathing or shortness of breath Dizziness Lightheadedness Fast or slow heart beat Flushing of the skin Muscle pain Feeling cold Hypoglycemia low blood sugar. Tell your healthcare provider right away if you have some or all of the following symptoms of hypoglycemia.
Tell your healthcare provider right away if you have some or all of the following symptoms of liver problems. Nausea Vomiting Loss of appetite Pain in the upper right part of the abdomen Flu-like symptoms Dark urine Yellowing of the skin or eyes Unusual bleeding or bruising Lack of energy Ovulation. Pioglitazone , like other thiazolidinediones, may stimulate ovulation in premenopausal women and increase the chance of pregnancy. Inform MD Back to Top. Especially tell your doctor if you: are allergic to Actoplus Met or to any of its ingredients have kidney problems have liver problems have heart problems have or have had bladder cancer have diabetic eye disease are pregnant or breastfeeding Tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements.
Adverse events associated with the use of ACTO plus met may include, but are not limited to, the following:. After initiation of ACTOS, and after dose increases, monitor patients carefully for signs and symptoms of heart failure e.
If heart failure develops, it should be managed according to current standards of care and discontinuation or dose reduction of ACTOS must be considered. ACTOS is not recommended in patients with symptomatic heart failure. Post-marketing cases of metformin-associated lactic acidosis have resulted in death, hypothermia, hypotension, and resistant bradyarrhythmias.
Symptoms included malaise, myalgias, respiratory distress, somnolence, and abdominal pain. Steps to reduce the risk of and manage metformin-associated lactic acidosis in these high risk groups are provided in the Full Prescribing Information.
If lactic acidosis is suspected, discontinue ACTO plus Met and institute general supportive measures in a hospital setting. Prompt hemodialysis is recommended. In each trial, there was a statistically significant reduction in blood glucose levels. However, it may cause a low blood sugar reaction and other side effects. If these effects are mild, they may go away within a few days or a couple of weeks. Call your doctor right away if you have serious side effects.
Serious side effects and their symptoms can include the following:. Low blood sugar can even be fatal. If you pass out because of a low sugar reaction or cannot swallow, someone will have to give you an injection of glucagon to treat the low sugar reaction.
You may need to go to the emergency room. Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare provider who knows your medical history. An interaction is when a substance changes the way a drug works.
This can be harmful or prevent the drug from working well. To help avoid interactions, your doctor should manage all of your medications carefully. Examples of these drugs include:. These dyes are used during certain imaging studies such as x-rays.
Examples of these drugs include calcium channel blockers, such as:. Examples of these drugs include histamine H2 blockers, such as:. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.
Taking it again could be fatal cause death. Alcohol may also raise or lower your blood sugar levels. If you drink alcohol, talk to your doctor. It may make your condition worse. For people with bladder cancer: This drug may increase the risk of bladder cancer.
If you have a history of the disease, talk to your doctor about whether this drug is safe for you. For people with heart failure and swelling edema : This drug can cause your body to retain extra fluid. This leads to swelling and weight gain, and may worsen your heart problems or lead to heart failure. Your doctor will monitor you for signs of heart failure while you take this drug.
For people with liver disease: Liver disease may put you at a higher risk of lactic acidosis, and pioglitazone may cause liver failure in some people.
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